Microfluidic Sperm Selection

The microfluidic sperm selection is an innovative method used during assisted reproduction cycles, particularly effective in response to the decline in semen quality caused by factors such as alcohol, smoking, poor diet, stress, and environmental pollution.

This technique is based on the principle of natural selection, using a chip with microchannels that simulate the environment of the female reproductive system.

The microchannels act as a filter, selecting only high-quality sperm. The selected sperm exhibit better morphology, non-fragmented DNA, and more than double the vitality and motility compared to unselected sperm.

Moreover, microfluidics reduces the risk of DNA damage and the formation of reactive oxygen species (ROS), contributing to a greater health of the sperm.

Advantages of Microfluidics

Microfluidics offers numerous advantages, including:
• Maximum imitation of the natural sperm selection mechanism.
• Selection of high-quality sperm with non-fragmented DNA.
• Increased speed of technique execution.
• Significant reduction in the risk of miscarriage.
• Reduction of oxidative stress in sperm.

Indications

This method is particularly indicated for patients with:
• High sperm DNA fragmentation.
• Repeated failed IUI attempts.
• Low oocyte fertilization rates using the ICSI method.
• Repeated miscarriages.
• Insufficient embryo quality.

However, it is important to note that microfluidics is not suitable for severely compromised semen, such as in cases of cryptozoospermia, severe oligozoospermia, and samples from biopsies or testicular aspirations.