ERA Test. Molecular Genetic Diagnostic Exam

CMR Torino ERA Test. Molecular Genetic Diagnostic Exam

The ERA Test (Endometrial Receptivity Array) is a patented molecular genetic diagnostic test by Igenomix, which evaluates the endometrial receptivity status of women to prevent embryo implantation failure.

This particular type of test can detect the specific "window of implantation" for each patient, allowing for a personalized embryo transfer (pET) and increasing the chances of success.

What does the ERA Test consist of?

Normally, the endometrium is examined with ultrasound, which allows for the assessment of its thickness and structure.

With the ERA Test, however, it is possible to evaluate the molecular expression of 248 genes related to endometrial receptivity status.

The first step of the test involves a simple and quick endometrial biopsy performed on an outpatient basis at our clinic, during a natural cycle or a substitute cycle with hormone therapy (HRT).

Subsequently, the sample is sent to the molecular genetics laboratory, which will analyze it using innovative parallel sequencing technology (Next-Generation Sequencing). The levels of gene expression detected allow us to assess whether the endometrium was receptive for embryo transfer on those days or if the so-called "window of implantation" is delayed (Non-Receptive).

Non-Invasive Prenatal Test (NIPT)

Applications and indications of the ERA Test

    The ERA Test is indicated for:
  • women who have experienced multiple implantation failures despite having morphologically good quality embryos.
  • women with a morphologically normal uterus and normal endometrial thickness (≥ 6 mm), who therefore do not constitute the problem.
The C.M.R. Turin Team

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