Endometriome Screening Test

CMR Torino Endometriome Screening Test

The Endometriome is a screening test that provides information about the intrauterine microbial environment. In fact, there is an important relationship between the endometrial microbiota and embryo implantation.

Specifically, in the presence of dysbiosis or pathogenic bacteria, the alteration of the endometrial microbiota can hinder the onset of pregnancy or be the cause of a miscarriage. The most prevalent endogenous bacterial species is Lactobacillus.

An important example of a pathology caused by the alteration of the endometrial microbiota is Chronic Endometritis (CE).

CE is characterized by a persistent inflammatory process affecting the endometrium and is generally asymptomatic, although in some cases it may present non-specific symptoms such as abnormal uterine bleeding, pelvic pain, or foul-smelling discharge.

It is estimated that in 39% of reproductive failures, the woman is affected by CE, with percentages rising to 60% in women with recurrent miscarriages (RPL) and 66% in women characterized by repeated failures.

What does the ENDOMETRIOME consist of?

It is a genetic screening test that evaluates the uterine microbial environment, specifically the optimal characteristics that allow for embryo implantation.

The Endometriome can be performed using a sample of tissue or endometrial fluid, taken at our clinic between the 15th and 25th days of the menstrual cycle or during the secretory phase in hormone replacement therapy (HRT) cycles.

Subsequently, the test involves genetic analysis using Next Generation Sequencing (NGS) conducted by the GENOMA molecular genetics laboratory in Rome, and if necessary, an appropriate corrective treatment.

    The NGS analysis provides:
  • a precise and comprehensive profile of the endometrial microbiota.
  • the percentage of Lactobacillus in the endometrial microbiota. If the report suggests dysbiosis or the presence of pathogens, appropriate corrective treatment can be proposed.
  • the possibility for the specialist to consciously choose the right time to transfer the embryo.
  • information on pathogenic bacteria causing CE to propose adequate antibiotic treatment.
Endometriome Screening Test

Applications and indications of the Endometriome

    The Endometriome is useful:
  • for patients with repeated embryo implantation failures.
  • for all patients trying to conceive, to assess the presence of undiagnosed dysbiosis or chronic endometritis that could negatively interfere with embryo implantation.
  • for patients with recurrent miscarriages.
The C.M.R. Turin Team

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