Heterologous Fertilization

CMR Torino Reproductive Medicine and Assisted Reproduction Center

GUARANTEED BLASTOCYST PROGRAM

72% positive results with a single cycle


This is a heterologous fertilization program (oocyte donation and double heterologous) that involves transferring cryopreserved embryos at the blastocyst stage, an advanced technique that offers the highest chances of achieving a successful pregnancy.

Our program guarantees the generation of at least 2 blastocysts.

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The heterologous fertilization represents the assisted reproductive treatment available to couples facing issues of irreversible sterility or infertility.

This path became accessible again in Italy in 2014, when the Constitutional Court, through the ruling 162/2014, declared the ban on heterologous fertilization imposed by law 40/2004 unconstitutional.

What is heterologous fertilization?

This treatment involves the use of assisted reproductive techniques, where gametes (sperm, oocytes, or both) from an external subject to the couple, namely a donor, are used.
We are talking about:

  • heterologous fertilization female, with oocyte donation (oocyte donation)
  • heterologous fertilization male, with sperm donation
  • heterologous fertilization with donation of oocytes and sperm (double heterologous)

Who can access the treatments?

Couples of different sexes with a diagnosis of infertility, whether married or cohabiting, where the woman is under 50 years old, can embark on a heterologous fertilization journey.

What will the couple's journey be like?

Only since 2014 has heterologous fertilization been re-admitted, which has resulted in a significantly reduced number of donors in Italy, necessitating recourse to tissue centers in foreign countries.
The CMR collaborates with leading European centers in the field to address the difficulty in obtaining reproductive cells (oocytes/sperm) properly cryopreserved according to the most modern and efficient techniques.

The strict Italian and European regulations (Legislative Decree 191/07 and Directive 17/2006, European Directives n.2004/23/CE, 2006/17/CE, and 2006/86/CE) establish criteria that ensure full safety in the selection of the donor and the protection of the recipients:

  • infectious and genetic tests
  • privacy protection
  • anonymity of the donor and recipients
  • each donor cannot generate more than 10 births, unless the couple wishes for a second child from the same donor
  • donors must be between 18 and 40 years old, and donors must be between 20 and 35 years old

How are donors chosen?

One of the most frequent requests concerns the similarity between parents and child, which is why CMR provides partner centers with all the phenotypic characteristics of the couple (ethnicity, blood type, RH factor, height, weight, skin color, eye color, hair type and color), always in compliance with the aforementioned safety regulations.

What must the couple do?

Both members of the couple will need to undergo tests to verify their suitability for the procedure.

  • In the case of heterologous fertilization with oocyte donation, the woman will need to follow a protocol to prepare the uterus for receiving the embryo generated from the in vitro fertilization of the donated oocytes with the partner's sperm.
  • In the case of sperm donation, the woman will need to follow an ovulation stimulation protocol followed by intrauterine insemination (heterologous insemination), or a multi-ovulation stimulation protocol followed by oocyte retrieval (pick-up) and in vitro fertilization using the donated sperm.
  • In the case of donation of both oocytes and sperm (embryo donation), the woman will need to follow a protocol to prepare the uterus for receiving the embryo generated from the in vitro fertilization of both donated oocytes and sperm.

What are the success rates?

In recent decades, motherhood has increasingly been postponed, especially in Italy, where fewer women are able to have a child between the ages of 28 and 35.
For this reason, more and more couples are resorting to heterologous fertilization techniques, particularly oocyte donation.

Oocyte donation currently represents the assisted reproductive technique with the highest success rates, between 60% and 70%, because using a donor of young age (20-35) helps to overcome the main factor of infertility, which is maternal age.

Quality and safety

CMR, with a view to continuous improvement and to ensure couples a high standard of quality in the specialized healthcare provided, has been applying a quality management system to its healthcare processes since 2011, certified by UNI EN ISO 9001-2015.

Following these principles, the Center has sought verification from a third-party certification body (Certiquality Milan) for the assisted reproductive process using donated gametes (heterologous ART) in compliance with current Italian and European regulations and safety criteria that ensure the highest quality standards in the operational methods adopted.

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The C.M.R. Turin Team

Online Consultation

The staff at CMR is here to support you through the activation of an ONLINE CONSULTATION desk, where they will answer all your questions to establish a first approach and begin an important journey together.